Andrea Twiss-Brooks is the Director of Humanities and Area Studies and is currently acting as Interim Director of Special Collections for the University of Chicago Library. In addition to these administrative roles, she has provided reference and consultation support for students, faculty, and staff in chemistry; geophysical sciences; and the history of science, medicine, and technology. She joined the University of Chicago Library in 1993 as chemistry librarian managing the Chemistry Library branch and serving on the science/medical reference team at the John Crerar Library. Her subject liaison responsibilities at various times encompassed geophysical sciences, history of science and medicine, physics, and non-medical biological sciences in addition to chemistry. In 2006, she was appointed Co-Director, Science Libraries, managing all aspects of collections that support teaching, learning and research in the physical, biological and medical sciences.

Her professional contributions include leadership positions in a variety of professional organizations, including American Chemical Society, Geoscience Information Society, and Medical Library Association (National Planning Committee/Local Assistance Committee chair for the 2014 Chicago meeting). She has also served on library advisory boards for a number of scientific and medical publishers.