Between the humanities and medicine there exist numerous definitions of the human, from differing perspectives and with different political implications. In recent decades, these disparate fields have built a tentative and growing dialogue. However, truly multidisciplinary research between the two remains rare. The Case of the Human is an ambitious collaborative project aimed not merely at translating existing theory across humanities and medical epistemologies, but rather at co-producing new, plural knowledge of the human that transcends epistemological boundaries. The project addresses the core questions: “What is the human?” and “What does the category of the human do?” The research team aims to create novel, multidisciplinary, and pluralistic knowledge on the human along three important axes: the human as body, as social, and as subject. We will achieve this goal through three key aims, each involving specific outputs: 1) co-developing novel, plural knowledge on the human through two working conferences (one of which was held during the first phase of the project), with distribution as a case-series in The Lancet; 2) establishing the University of Chicago as a hub in global medical humanities networks through a medical humanities institution-building conference, and convening Visiting Fellows to implement, refine, and disseminate, our novel interdisciplinary methodology; and 3) a visual artistic exploration the human and the case form through student artistic workshops and a graphic medicine exhibition. We seek to advance this project’s innovative scholarship that began with the Neubauer Collegium by scaling up its successes of interdisciplinary collaborations and centering artistic understandings of the human.