Game Changer Chicago (GCC) Design Lab is an initiative of the Center for Interdisciplinary Inquiry and Innovation in Sexual and Reproductive Health (Ci3) at the University of Chicago. Co-founded by Drs. Patrick Jagoda (Assistant Professor of English) and Melissa Gilliam (Professor of Obstetrics/Gynecology and Pediatrics), the GCC Design Lab created workshops in which high school aged youth – recruited primarily from underserved schools on Chicago’s South Side – collaborated with faculty, staff and fellows (undergraduate and graduate students in the humanities and arts) on digital stories, transmedia games and new media art projects. The GCC Design Lab is both a maker-space and a research lab. As a maker-space, we have a strong commitment to developing youth-led products, running game design workshops, and creating games for national and transnational dissemination. As a research lab, we promoted continued work at the intersection of art, narrative, health, and technology with an eye to critical thinking and healthy social and emotional outcomes.