Between the humanities and medicine there exist numerous definitions of the human, from different perspectives and with different political implications. In recent decades, these disparate fields have built a tentative and growing dialogue. However, truly multidisciplinary research between the two is still rare. This project aims not merely at translating existing theory across humanities and medicine, but rather at co-producing new plural knowledge of the human that transcends epistemological boundaries. As such, The Case of the Human proposes one ambitious project addressing core questions: “What is the human?” and “What does the category of the human do?” Our project is thus to create novel, multidisciplinary, and pluralistic knowledge on the human along three important axes: the human as body, as social, and as subject. We achieve this goal through three key aims, each involving specific outputs: 1) co-developing novel, plural knowledge on the human, through a multidisciplinary research conference series; 2) disseminating new knowledges on the human, through a collaborative case series published in The Lancet; and 3) fostering community reflection and personal engagement on the human, through collective writing on this collaborative process. The project is led by a group of scholars and practitioners in medicine, the humanities, and the humanistic social sciences, in partnership with Janna Palmer, Executive Editor at The Lancet. The Lancet editorial team will review the final submitted essays, and will select content for publication in the journal.